Synthetic Gene Expression Circuits for Designing Precision Tools in Oncology
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چکیده
منابع مشابه
Synthetic Gene Expression Circuits for Designing Precision Tools in Oncology
Precision medicine in oncology needs to enhance its capabilities to match diagnostic and therapeutic technologies to individual patients. Synthetic biology streamlines the design and construction of functionalized devices through standardization and rational engineering of basic biological elements decoupled from their natural context. Remarkable improvements have opened the prospects for the a...
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Barbara Jusiak1,2, Ramiz Daniel1,3, Fahim Farzadfard2–5, Lior Nissim1,3, Oliver Purcell2,3, Jacob Rubens1,3,5, and Timothy K. Lu1–6 1Massachusetts Institute of Technology, Research Laboratory of Electronics, Cambridge, MA 02139, USA 2Massachusetts Institute of Technology, Department of Biological Engineering, Cambridge, MA 02139, USA 3Massachusetts Institute of Technology, Synthetic Biology Cen...
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A major goal of synthetic biology is to develop a deeper understanding of biological design principles from the bottom up, by building circuits and studying their behavior in cells. Investigators initially sought to design circuits "from scratch" that functioned as independently as possible from the underlying cellular system. More recently, researchers have begun to develop a new generation of...
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For the development and evaluation of CADtools for partitioning, floorplanning, placement, and routing of digital circuits, a huge amount of benchmark circuits with suitable characteristic parameters is required. Observing the lack of industrial benchmark circuits available for use in evaluation tools, one could consider to actually generate synthetic circuits. In this paper, we extend a graph-...
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ژورنال
عنوان ژورنال: Frontiers in Cell and Developmental Biology
سال: 2017
ISSN: 2296-634X
DOI: 10.3389/fcell.2017.00077